Archive for February 11th, 2009

Genetic Testing for Neonatal Diabetes

Neonatal diabetes is characterized by insulin-sensitive hyperglycemia usually diagnosed within the first six months of life. The prevalence of this condition is around 1 in 400,000 births. About 50% of all cases of neonatal diabetes are an effect of mutations in either the sulfonylurea receptor -1 gene (SUR1) or the KIR6.2 gene (polymorphisms of KCNJ11). Researchers at Oxford University in the United Kingdom headed by Frances Ashcroft have now designed a mouse model of the disease that they stro…